PRECISION MEDICINE · GLENVIEW, ILLINOIS

Decoding the Biology of
Race, Ciliary Signaling,
and Inflammatory
Disease - Through AI/ML

McGenome LLC develops race-calibrated molecular diagnostic platforms for rare and complex diseases where existing tools systematically fail the patients who need them most. Two patent-pending platforms. One founding mission.

SarcoActivity™Patent Pending · US 63/078,909 · May 31 2026
KIF7-CilioPanel™Patent Pending · US 64/085,517
nmMLCK PlatformPatent Pending · Docket MCG-2025-001-PPA
NIH STTRPhase I Applications · NHLBI · NIMHD · NICHD · September 2026
Published ScienceAlafghani et al. · Human Genomics · 2026
Patent-Pending Platforms

Two Platforms. Two Unmet Needs.

Developed from 30 years of kinesin biology, ciliary signaling, and molecular genetics - translated into precision diagnostic tools for the patients most underserved by existing standards.

Sarcoidosis · Health Equity

SarcoActivity™

Race-Calibrated AI Sarcoidosis Monitoring Platform

Serum ACE monitoring fails African American sarcoidosis patients due to two independent mechanisms: the rs1799752 II genotype polymorphism and ACE inhibitor pharmacological suppression - producing false-reassuring results in the population with 14× higher sarcoidosis mortality. SarcoActivity™ is a 7-component AI/ML platform providing race-calibrated composite disease activity monitoring, endotype classification, and drug response prediction.

US PPA No. 63/078,909 · Filed May 31, 2026 · Patent Pending
NIH STTR Phase I · NHLBI + NIMHD · $299,800 direct · Sep 2026 submission
Prof. Nadera Sweiss, MD · UIC Bernie Mac STAR Center · Co-PI
7 components · 16 patent claims · BFD · SAI · FPP · MOEC · DRPE · NBDP · CDSS
Explore SarcoActivity™ →
Pediatric Rare Disease · Ciliopathy

KIF7-CilioPanel™

Molecular Diagnostic Platform for JSRD Ciliopathy

Joubert Syndrome and Related Disorders (JSRD) is a rare autosomal recessive ciliopathy affecting consanguineous populations globally, with a confirmed genetic diagnosis in fewer than 60% of patients using current single-gene testing. KIF7-CilioPanel™ is an 11-gene tiered NGS diagnostic platform combining functional Hedgehog pathway assays and the JCiloScore™ machine learning composite for JSRD diagnosis, prognosis, and organ surveillance planning.

US PPA MCGEN-002-PROV · Filed May 2026 · Patent Pending
Alafghani et al. · Human Genomics · 2026 · doi:10.1186/s40246-026-00953-8
NIH STTR Phase I · NICHD · $300,000 direct · Sep 2026 submission
King Abdulaziz University, Jeddah · Saudi JSRD consanguineous cohort
Explore KIF7-CilioPanel™ →
30

Years of Published Science

Peer-reviewed research in Human Genomics, J Mol Biol, PNAS, DNA Research, J Cell Science, and Genomics - kinesin biology, ciliary signaling, and molecular genetics from C. elegans to human disease.

2

Patent-Pending Platforms

Two AI/ML molecular diagnostic platforms filed at USPTO in 2026 - SarcoActivity™ (US 63/078,909) and KIF7-CilioPanel™ (MCGEN-002-PROV) - addressing sarcoidosis health equity and pediatric rare ciliopathy.

2

NIH STTR Applications

Phase I STTR applications submitted to NHLBI, NIMHD, and NICHD - with academic partners at UIC Bernie Mac STAR Center (Chicago) and King Abdulaziz University (Jeddah, Saudi Arabia).